Signatures of Dobzhansky–Muller Incompatibilities in the Genomes of Recombinant Inbred Lines

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GENETICS | INVESTIGATION Signatures of Dobzhansky-Muller Incompatibilities in the Genomes of Recombinant Inbred Lines

In the construction of Recombinant Inbred Lines (RILs) from two divergent inbred parents certain genotype (or epigenotype) combinations may be functionally “incompatible” when brought together in the genomes of the progeny, thus resulting in sterility or lower fertility. Natural selection against these epistatic combinations during inbreeding can change haplotype frequencies and distort linkage...

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Signatures of Dobzhansky-Muller Incompatibilities in the Genomes of Recombinant Inbred Lines.

In the construction of recombinant inbred lines (RILs) from two divergent inbred parents certain genotype (or epigenotype) combinations may be functionally "incompatible" when brought together in the genomes of the progeny, thus resulting in sterility or lower fertility. Natural selection against these epistatic combinations during inbreeding can change haplotype frequencies and distort linkage...

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ژورنال

عنوان ژورنال: Genetics

سال: 2015

ISSN: 1943-2631

DOI: 10.1534/genetics.115.179473